Epigenetics plays a key role in cellular development and function. Alterations to the
epigenome are thought to capture and mediate the effects of genetic and environmental risk …

Omics data contain signals from the molecular, physical, and kinetic inter-and intracellular
interactions that control biological systems. Matrix factorization (MF) techniques can reveal …

Antitumoral immunity requires organized, spatially nuanced interactions between
components of the immune tumor microenvironment (iTME). Understanding this coordinated …

Technological advances have enabled the profiling of multiple molecular layers at single-
cell resolution, assaying cells from multiple samples or conditions. Consequently, there is a …

Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete
description of specific immune biomarkers. We present here a comprehensive multi-omic …

Abstract Characterization of the molecular function of the human genome and its variation
across individuals is essential for identifying the cellular mechanisms that underlie human …

Multi‐omics studies promise the improved characterization of biological processes across
molecular layers. However, methods for the unsupervised integration of the resulting …

Transcriptome-wide association analysis is a powerful approach to studying the genetic
architecture of complex traits. A key component of this approach is to build a model to impute …

Perceptions, thoughts, and actions unfold over millisecond timescales, while learned
behaviors can require many days to mature. While recent experimental advances enable …

Genome-wide association studies have implicated around 250 genomic regions in
predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for …