Thalassemias are a group of congenital hemoglobin (Hb) disorders distinguished by
dwindling or total curtailment of production of one or more globin chains of hemoglobin …

Background Beta‐thalassaemia is an inherited blood disorder that reduces the production of
haemoglobin. The most severe form requires recurrent blood transfusions, which can lead to …

Background Patients with transfusion-dependent thalassemia (TDT) require lifelong blood
transfusions and iron chelation therapy. Thus, patients afflicted with TDT often have to …

Hydroxyurea is an antimetabolite drug that induces fetal haemoglobin in sickle cell disease.
However, its clinical usefulness in β-thalassaemia is unproven. We conducted a …

Background β-thalassaemia major poses a substantial economic burden, especially in
adults. We aimed to estimate the economic burden of adult patients with β-thalassaemia …

Background Transfusion-dependent thalassaemia (TDT) is a hereditary blood disorder in
which blood transfusion is the mainstay treatment to prolong survival and improve quality of …

Background Patients with β-thalassemia major (β-TM), predominantly adult patients, are
associated with physical, mental, and social problems, that result in decreased quality of life …

Background The informal caregivers of adult patients with β-thalassemia major (β-TM) bear
not only physical but also emotional and economic pressures of providing care. This study is …

Thalassemia is one of the most prevalent monogenic disorders in low-and middle-income
countries (LMICs). There are an estimated 270 million carriers of hemoglobinopathies …

Sri Lanka, a country with 22 million people, has nearly 2000 thalassemia patients with
severe thalassemia, two-thirds of whom have beta thalassemia major (TM). The current …