Medial arterial calcification (MAC) is a chronic systemic vascular disorder distinct from
atherosclerosis that is frequently but not always associated with diabetes mellitus, chronic …

Cancers are able to grow by subverting immune suppressive pathways, to prevent the
malignant cells as being recognized as dangerous or foreign. This mechanism prevents the …

The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration,
magnitude, and chemical nature of purinergic signals delivered to immune cells through the …

Vascular calcifications (VCs) are actively regulated biological processes associated with
crystallization of hydroxyapatite in the extracellular matrix and in cells of the media (VCm) or …

The first full publications on the biological effects of the diphosphonates, later renamed
bisphosphonates, appeared in 1969, so it is timely after 40 years to review the history of their …

This review focuses on the association between vascular calcification and arterial stiffness,
highlighting the important genetic factors, systemic and local microenvironmental signals …

Efforts to identify the genetic underpinnings of rare undiagnosed diseases increasingly
involve the use of next-generation sequencing and comparative genomic hybridization …

Pseudoxanthoma elasticum (PXE) is a genetic metabolic disease with autosomal recessive
inheritance caused by mutations in the ABCC6 gene. The lack of functional ABCC6 protein …

Spontaneous pathologic arterial calcifications in childhood can occur in generalized arterial
calcification of infancy (GACI) or in pseudoxanthoma elasticum (PXE). GACI is associated …

Pseudoxanthoma elasticum (PXE) is an autosomal recessive disease characterized by
progressive ectopic mineralization of the skin, eyes, and arteries, for which no effective …