Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Neurodegenerative diseases (NDDs) represent a huge social burden, particularly in
Alzheimer's disease (AD) in which all proposed treatments investigated in murine models …

Saffron (Crocus sativus L.) has been previously reported to be active as a protective agent in
multiple experimental models of oxidative stress, inflammation and cancer. These findings …

Crocus sativus L. belongs to the Iridaceae family and it is commonly known as saffron. The
different cultures together with the geoclimatic characteristics of the territory determine a …

Retinitis pigmentosa (RP) is an important cause of irreversible blindness worldwide and
lacks effective treatment strategies. Although mutations are the primary cause of RP …

Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a
medicinal plant. It currently has numerous therapeutic properties attributed to it, such as …

Different studies have confirmed P2X7 receptor-mediated inflammatory mediators play a key
role in the development of pain. P2X7 receptor activation can induce the development of …

Saffron (Crocus sativus L.) and its main constituents, ie, crocin and crocetin, are natural
carotenoid compounds, which have been reported to possess a wide spectrum of properties …

Neuropathic Pain (NPP) is caused by direct or indirect damage to the nervous system and is
a common symptom of many diseases. Clinically, drugs are usually used to suppress pain …

Retinitis pigmentosa (RP) is a form of retinal degeneration characterized by primary
degeneration of rod photoreceptors followed by a secondary cone loss that leads to vision …