Gametes are highly specialized cell types produced by a complex differentiation process.
Production of viable oocytes requires a series of precise and coordinated molecular events …

The long-term survival of any multicellular species depends on the success of its germline in
producing high-quality gametes and maximizing survival of the offspring. Studies in …

The Drosophila ovary is a widely used model for germ cell and somatic tissue biology. Here
we use single-cell RNA-sequencing (scRNA-seq) to build a comprehensive cell atlas of the …

The niche has been shown to control stem cell self-renewal in different tissue types and
organisms. Recently, a separate niche has been proposed to control stem cell progeny …

Stem cell maintenance is established by neighboring niche cells that promote stem cell self-
renewal. However, it is poorly understood how stem cell activity is regulated by systemic …

Wnt signalling is an essential pathway in embryogenesis, differentiation, cell motility,
development, and adult tissue homeostasis in vertebrates. The Wnt signalling network can …

In the germarium of the Drosophila ovary, developing germline cysts are surrounded by a
population of somatic escort cells that are known to function as the niche cells for germline …

The niche controls stem cell self-renewal and progenitor differentiation for maintaining adult
tissue homeostasis in various organisms. However, it remains unclear whether the niche is …

Adult stem cells continuously undergo self-renewal and generate differentiated cells. In the
Drosophila ovary, two separate niches control germ line stem cell (GSC) self-renewal and …

In the mid-1960s, bone morphogenetic proteins (BMPs) were first identified in the extracts of
bone to have the remarkable ability to induce heterotopic bone. When the Drosophila gene …