Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

A complete understanding of protein function and dynamics requires the characterization of
the multiple thermodynamic states, including the denatured state ensemble (DSE). Whereas …

Despite transformative advances in protein design with deep learning, the design of small-
molecule–binding proteins and sensors for arbitrary ligands remains a grand challenge …

Highlights•De novo single chain proteins can be designed with atomic accuracy.•Multi-chain
protein assemblies can be created based on different symmetries.•Extremely large …

Parallel β-sheet-containing repeat proteins often display a structural motif in which
conserved asparagines form a continuous ladder buried within the hydrophobic core. In …

The complexity of designed bionano-scale architectures is rapidly increasing mainly due to
the expanding field of DNA-origami technology and accurate protein design approaches …

Top7 is a de novo designed protein whose amino acid sequence has no evolutional trace.
Such a property makes Top7 a suitable scaffold for studying the pure nature of protein and …

Abstract As Richard Feynman has observed, what we are observing living organisms, more
specifically, how cells are working is a fundamental element to understand biology better …

Die CXXC-Oxidoreduktasen steuern eine Vielzahl zellulärer Redoxprozesse. Dabei ist
unklar, wie deren Proteinstruktur die beobachtbare Aktivitätsbreite erzeugt. Ziel der Arbeit …

In dieser Arbeit wurde der erste Designversuch zur Umwandlung des Strukturproteins M7
hin zu einem redoxaktiven Protein realisiert. Dabei widmet sich diese Arbeit primär den …