Novel cellular functions of very long chain-fatty acids: insight from ELOVL4 mutations
F Deák, RE Anderson, JL Fessler… - Frontiers in cellular …, 2019 - frontiersin.org
Elongation of Very Long chain fatty acids-4 (ELOVL4) protein is a member of the ELOVL
family of fatty acid elongases that is collectively responsible for catalyzing formation of long …
family of fatty acid elongases that is collectively responsible for catalyzing formation of long …
[HTML][HTML] Maternal treatment with sodium butyrate reduces the development of autism-like traits in mice offspring
C Cristiano, E Hoxha, P Lippiello, I Balbo… - Biomedicine & …, 2022 - Elsevier
Several studies indicate a relationship between maternal gut microbiota alteration and
increased risk of autism spectrum disorders (ASD) in offspring. The possibility of …
increased risk of autism spectrum disorders (ASD) in offspring. The possibility of …
Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity
Purkinje cells in the cerebellum are among the largest neurons in the brain and have been
extensively investigated in rodents. However, their morphological and physiological …
extensively investigated in rodents. However, their morphological and physiological …
Chronic suppression of STIM1-mediated calcium signaling in Purkinje cells rescues the cerebellar pathology in spinocerebellar ataxia type 2
PA Egorova, KS Marinina, IB Bezprozvanny - Biochimica et Biophysica Acta …, 2023 - Elsevier
Distorted neuronal calcium signaling has been reported in many neurodegenerative
disorders, including different types of spinocerebellar ataxias (SCAs). Cerebellar Purkinje …
disorders, including different types of spinocerebellar ataxias (SCAs). Cerebellar Purkinje …
Ovine ELOVL5 and FASN genes polymorphisms and their correlations with sheep tail fat deposition
L Zhao, F Li, T Liu, L Yuan, X Zhang, D Zhang, X Li… - Gene, 2022 - Elsevier
Reducing tail fat deposition can increase the economic value of a carcass and improve feed
efficiency. This study aimed to explore ELOVL5 and FASN polymorphisms associated with …
efficiency. This study aimed to explore ELOVL5 and FASN polymorphisms associated with …
Long-term efficacy of docosahexaenoic acid (DHA) for spinocerebellar ataxia 38 (SCA38) treatment: an open label extension study
M Manes, A Alberici, E Di Gregorio, L Boccone… - Parkinsonism & related …, 2019 - Elsevier
Abstract Introduction Spinocerebellar Ataxia 38 (SCA38) is caused by ELOVL5 gene
mutation, with significant reduction of serum docosahexaenoic acid (DHA) levels. DHA …
mutation, with significant reduction of serum docosahexaenoic acid (DHA) levels. DHA …
SCA34 caused by ELOVL4 L168F mutation is a lysosomal lipid storage disease sharing pathology features with neuronal ceroid lipofuscinosis and peroxisomal …
Abstract Spinocerebellar ataxia 34 (SCA34) is a late-onset progressive ataxia caused by a
mutation in ELOVL4, a gene involved in the biosynthesis of very long-chain fatty acids …
mutation in ELOVL4, a gene involved in the biosynthesis of very long-chain fatty acids …
Effect of naoxintong capsule on microglia and proteomics of cortex after myocardial infarction in rats
M Chang, Y Lei, J Zhang, J Xu, H Wu, S Tang… - Molecular …, 2024 - Springer
Neuroinflammation caused by microglia in the central nervous system (CNS) is observed
after myocardial infarction (MI). However, the inflammatory response mechanism remains …
after myocardial infarction (MI). However, the inflammatory response mechanism remains …
W246G mutant ELOVL4 impairs synaptic plasticity in parallel and climbing fibers and causes motor defects in a rat model of SCA34
RY Nagaraja, DM Sherry, JL Fessler, MA Stiles… - Molecular …, 2021 - Springer
Spinocerebellar ataxia (SCA) is a neurodegenerative disorder characterized by ataxia and
cerebellar atrophy. A number of different mutations gives rise to different types of SCA with …
cerebellar atrophy. A number of different mutations gives rise to different types of SCA with …
In human and mouse spino-cerebellar tissue, ataxin-2 expansion affects ceramide-sphingomyelin metabolism
Ataxin-2 (human gene symbol ATXN2) acts during stress responses, modulating mRNA
translation and nutrient metabolism. Ataxin-2 knockout mice exhibit progressive obesity …
translation and nutrient metabolism. Ataxin-2 knockout mice exhibit progressive obesity …