Folic acid, a B vitamin, is vital for early neurodevelopment and is well known for its protective
effect against neural tube defects. Various national health agencies worldwide recommend …

Abstract Spinocerebellar ataxia type 2 (SCA2) is a polyglutamine disorder caused by a
pathological expansion of CAG repeats in ATXN2 gene. SCA2 is accompanied by cerebellar …

Fifteen to 20% of pregnant women may exceed the recommended intake of folic acid (FA) by
more than four-fold. This excess could compromise neurocognitive and motor development …

Background: Folic acid plays an important role in early brain development of offspring,
including proliferation and differentiation of neural stem cells known to impact the function of …

Methotrexate (MTX) is a folic acid antagonist and widely used for acute lymphoblastic
leukemia (ALL) in children. MTX is associated with acute and chronic neurotoxicity during …

Focal brain ischemia is best studied in neocortex and striatum. Both show highly vulnerable
neurons and high susceptibility to spreading depolarization (SD). Therefore, it has been …

Objective: The cerebellum has a long, protracted developmental period; therefore, it is more
sensitive to intrauterine and postnatal insults like nutritional deficiencies. Folate is an …

The cerebellum has a long, protracted developmental period that spans from the embryonic
to postnatal periods; as a result, it is more sensitive to intrauterine and postnatal insults like …

Diabetes mellitus (DM) is a metabolic disorder that causes severe complications. Thus, the
aims of this study were to investigate the influence of DM and folic acid treatment on liver …

Background Maternal folate usage is essential for neurodevelopment, but its effects on
cerebellar structure are unclear. Cerebellum undergoes a protracted period of development …