An increasing number of primary immunodeficiencies (PIDs) have been identified over the
last decade, which are caused by deleterious mutations in genes encoding for proteins …

Traditionally, primary immune deficiencies have been defined based on increased
susceptibility to recurrent and/or severe infections. However, immune dysregulation …

Long noncoding RNAs (lncRNAs) have been associated with cancer immunity regulation
and the tumor microenvironment (TME). However, functions of lncRNAs of tumor-infiltrating …

Epstein–Barr virus (EBV) is a ubiquitous human pathogen, infecting> 90% of the adult
population. In the vast majority of healthy individuals, infection with EBV runs a relatively …

Highlights•Interleukin (IL)-6/STAT3/ERBIN pathway retrains human Th2 cells.•IFNγ, but not
IL-12, is a negative regulator of human Th2 cell development.•STAT6 is a key driver of Th2 …

Simple Summary Epstein–Barr Virus (EBV) is a common virus that is readily controlled by a
healthy immune system and rarely causes serious problems in infected people. However …

The advent of flow cytometry has revolutionized the way we approach our research and
answer specific scientific questions. The flow cytometer has also become a mainstream …

Systemic lupus erythematosus (SLE) is characterized by high levels of autoantibodies and
multiorgan tissue damage. The pathogenesis of splenomegaly in SLE remains unknown. In …

Random VDJ recombination early in T and B cell development enables the adaptive
immune system to recognize a vast array of evolving pathogens via antigen receptors …

Biallelic inactivating mutations in DOCK8 cause a combined immunodeficiency
characterized by severe pathogen infections, eczema, allergies, malignancy, and impaired …