Abstract In 2009, the American Cancer Society (ACS) Prostate Cancer Advisory Committee
began the process of a complete update of recommendations for early prostate cancer …

Background Any form of screening aims to reduce disease‐specific and overall mortality,
and to improve a person's future quality of life. Screening for prostate cancer has generated …

Importance Prostate cancer screening remains controversial because potential mortality or
quality-of-life benefits may be outweighed by harms from overdetection and overtreatment …

Background Cabazitaxel is a novel tubulin-binding taxane drug with antitumour activity in
docetaxel-resistant cancers. We aimed to compare the efficacy and safety of cabazitaxel …

Background The prostate component of the Prostate, Lung, Colorectal, and Ovarian (PLCO)
Cancer Screening Trial was undertaken to determine whether there is a reduction in …

BACKGROUND: Overdiagnosis and subsequent overtreatment are important side effects of
screening for, and early detection of, prostate cancer (PCa). Active surveillance (AS) is of …

Background Prostate cancer is one of the leading causes of death from malignant disease
among men in the developed world. One strategy to decrease the risk of death from this …

Background After 11 years of follow-up, the European Randomized Study of Screening for
Prostate Cancer (ERSPC) reported a 29% reduction in prostate-cancer mortality among men …

BACKGROUND: Screening for prostate cancer (PC) is controversial due to uncertainties
about its efficiency. OBJECTIVE: We aimed to develop strategies to reduce the number of …

Key Clinical Points Prostate-Cancer Screening The introduction of prostate-specific antigen
(PSA) testing has nearly doubled the lifetime risk of receiving a diagnosis of prostate cancer …