Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances
Z Yu, C Xu, B Song, S Zhang, C Chen, C Li… - Journal of Translational …, 2023 - Springer
Cancer remains the leading cause of death around the world. In cancer treatment, over 50%
of cancer patients receive radiotherapy alone or in multimodal combinations with other …
of cancer patients receive radiotherapy alone or in multimodal combinations with other …
Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis
Y Wang, S Chen, S Bao, L Yao, Z Wen, L Xu… - Frontiers in …, 2024 - frontiersin.org
This review explores the mechanisms of chronic radiation-induced skin injury fibrosis,
focusing on the transition from acute radiation damage to a chronic fibrotic state. It reviewed …
focusing on the transition from acute radiation damage to a chronic fibrotic state. It reviewed …
DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell–mediated antitumor immunity
Programmed cell death protein 1 (PD-1) immune checkpoint blockade therapy has
revolutionized cancer treatment. Although PD-1 blockade is effective in a subset of patients …
revolutionized cancer treatment. Although PD-1 blockade is effective in a subset of patients …
[HTML][HTML] TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3'neo-enhancer
T-cell acute lymphocytic leukemia protein 1 (TAL1) is one of the most frequently deregulated
oncogenes in T-cell acute lymphoblastic leukemia (T-ALL). Its deregulation can occur …
oncogenes in T-cell acute lymphoblastic leukemia (T-ALL). Its deregulation can occur …
MEOX2 homeobox gene promotes growth of malignant gliomas
A Schönrock, E Heinzelmann, B Steffl… - Neuro …, 2022 - academic.oup.com
Background Glioblastoma (GBM) is an aggressive tumor that frequently exhibits gain of
chromosome 7, loss of chromosome 10, and aberrantly activated receptor tyrosine kinase …
chromosome 7, loss of chromosome 10, and aberrantly activated receptor tyrosine kinase …
Aberrant MNX1 expression associated with t (7; 12)(q36; p13) pediatric acute myeloid leukemia induces the disease through altering histone methylation
A Waraky, A Östlund, T Nilsson, D Weichenhan… - …, 2023 - pmc.ncbi.nlm.nih.gov
Certain subtypes of acute myeloid leukemia (AML) in children have inferior outcome, such
as AML with translocation t (7; 12)(q36; p13) leading to an MNX1:: ETV6 fusion along with …
as AML with translocation t (7; 12)(q36; p13) leading to an MNX1:: ETV6 fusion along with …
ARID1A regulates DNA repair through chromatin organization and its deficiency triggers DNA damage-mediated anti-tumor immune response
A Bakr, GD Corte, O Veselinov, S Kelekçi… - Nucleic Acids …, 2024 - academic.oup.com
AT-rich interaction domain protein 1A (ARID1A), a SWI/SNF chromatin remodeling complex
subunit, is frequently mutated across various cancer entities. Loss of ARID1A leads to DNA …
subunit, is frequently mutated across various cancer entities. Loss of ARID1A leads to DNA …
Selective inhibitors of bromodomain BD1 and BD2 of BET proteins modulate radiation‐induced profibrotic fibroblast responses
CS Liu, I Rioja, A Bakr, MR Veldwijk… - … Journal of Cancer, 2022 - Wiley Online Library
Radiotherapy can induce various adverse effects including fibrosis in cancer patients.
Radiation‐induced aberrant expression of profibrotic genes has been associated with …
Radiation‐induced aberrant expression of profibrotic genes has been associated with …
Mnx1 induces leukemia transformation through altering histone methylation in a model of pediatric t (7; 12) acute myeloid leukemia
A Waraky, A Östlund, T Nilsson, D Weichenhan… - BiorXiv, 2022 - biorxiv.org
Acute myeloid leukemia (AML) in children with certain genetic aberrations is still associated
with inferior outcome. One of these AML subtypes has a translocation t (7; 12)(q36; p13) and …
with inferior outcome. One of these AML subtypes has a translocation t (7; 12)(q36; p13) and …
Long-term outcomes of an international cooperative study of intraoperative radiotherapy upfront boost with low energy x-rays in breast cancer
GR Sarria, ML Ramos, A Palacios, R Del Castillo… - Frontiers in …, 2022 - frontiersin.org
Purpose The purpose of this study was to assess the effectivity of upfront kilovoltage
intraoperative radiotherapy (IORT) as a boost in high-risk early-stage breast cancer patients …
intraoperative radiotherapy (IORT) as a boost in high-risk early-stage breast cancer patients …