Polyphenol supplementation during early life has been associated with a reduction of
oxidative stress and neuroinflammation in diseases caused by oxygen deprivation, including …

Migraine is a common condition in mitochondrial diseases, with a higher prevalence than in
the general population. Although several clinical studies support the hypothesis that …

Different mitochondrial DNA (mtDNA) mutations have been identified to cause mitochondrial
encephalopathy, lactate acidosis and stroke-like episodes (MELAS). The underlying genetic …

Mutations of mtDNA, due to their higher frequency of occurrence compared to nuclear DNA
mutations, are the most promising biomarkers for assessing predisposition of the occurrence …

Mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) mostly
occur in children. The point mutation A3243G of mitochondrial DNA (mtDNA) may work as a …

Abstract Mitochondrial DNA m. 3243A> G mutation causes mitochondrial encephalopathy,
lactic acidosis, and stroke-like episodes (MELAS) and its associated multi-organ disorders …

Human hereditary epilepsy has been found related to ion channel mutations in voltage-
gated channels (Na+, K+, Ca2+, Cl-), ligand gated channels (GABA receptors), and G …

Background: Mitochondrial diseases are a group of multisystem heterogeneous diseases
caused by pathologic dysfunction of the mitochondrial respiratory chain. A wide range of …

Studies have shown that mitochondrial DNA (mtDNA) can be exchanged between tissues;
however, the mechanism (s) behind this phenomenon remain unclear. Exosomes and other …

Background Migraine is a common neurological disorder which affects a large proportion of
the population. The Norfolk Island population is a genetically isolated population and is an …