Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …

Epilepsy comprises more than 40 clinical syndromes affecting millions of patients and
families worldwide. To decode the molecular and pathological framework of epilepsy …

Abstract Developmental and Epileptic Encephalopathies (DEE) are a genetically diverse
group of severe, early onset seizure disorders. DEE are normally identified clinically in the …

Epilepsy is a highly prevalent neurological disease and anti-epileptic drugs (AED) are
almost the unique clinical treatment option. A disbalanced brain renin–angiotensin system …

Epilepsy is one of the most prevalent neurological diseases and although numerous novel
anticonvulsants have been approved, the proportion of patients who are refractory to …

Epilepsy is a chronic brain disease with a global prevalence of 70 million people. According
to the World Health Organization, roughly 5 million new cases are diagnosed every year …

Introduction: Comorbidities of epilepsy may significantly interfere with its treatment as
diseases in the general population are also encountered in epilepsy patients and some of …

Introduction Angiotensin II receptor blockers are widely used for the treatment of arterial
hypertension and heart failure. However, recent studies on animal models of seizures …

Epilepsy is a complex neurological condition wherein patients have recurrent spontaneous
seizures leading to numerous physical and mental challenges. De novo mutations cause …