Nitric Oxide (NO) is a soluble endogenous gas with various biological functions like
signaling, and working as an effector molecule or metabolic regulator. In response to …

This review focuses on the production of nitric oxide (NO) by inducible nitric oxide synthase
(iNOS) and its regulation under physiological and pathophysiological conditions. NO is an …

c-Jun N-terminal kinase (JNK), or stress-activated protein kinase, is an important member of
the mitogen-activated protein kinase superfamily, the members of which are readily …

Primary hepatocytes and their cultures are a simple but versatile, well-controlled, and
relatively easy to handle in vitro system that is well-accepted for investigating xenobiotic …

Nitric oxide (NO) is a multi-faceted molecule with dichotomous regulatory roles in many
areas of biology. The complexity of its biological effects is a consequence of its numerous …

The effects of nitric oxide in biological systems depend on its steady-state concentration and
where it is being produced. The organ where nitric oxide is produced is relevant, and within …

Nitric oxide (NO) is a short-life molecule produced by the enzyme known as the nitric oxide
synthase (NOS), in a reaction that converts arginine and oxygen into citrulline and NO …

Chronic inflammation of gastrointestinal tissues is a well-recognized risk factor for the
development of epithelial cell-derived malignancies. Although the inflammatory mediators …

Liver diseases such as hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma are one of
the major health challenges in the world and many conditions such as inadequate nutrition …

Primary hepatocellular carcinoma (HCC) is one of the most common malignancies and has
the fourth highest mortality rate worldwide. The major risk factors, including chronic …