NK cell dysfunction is linked with disease severity in SARS‐CoV‐2 patients
SARS‐CoV‐2 first raised from Wuhan City, Hubei Province in November 2019. The
respiratory disorder, cough, weakness, fever are the main clinical symptoms of coronavirus …
respiratory disorder, cough, weakness, fever are the main clinical symptoms of coronavirus …
[HTML][HTML] Involvement of Inheritance in Determining Telomere Length beyond Environmental and Lifestyle Factors
NM Gold, MN Okeke, Y He - Aging and Disease, 2023 - pmc.ncbi.nlm.nih.gov
All linear chromosomal ends have specific DNA-protein complexes called telomeres.
Telomeres serve as a" molecular clock" to estimate the potential length of cell replication …
Telomeres serve as a" molecular clock" to estimate the potential length of cell replication …
Synergistic effect of cobalt ferrite-graphene oxide based hyperthermia and capsaicin to induce apoptosis and inhibit telomerase activity in breast cancer cells
SA Lajevardian, A Alibakhshi… - Advances in Natural …, 2024 - iopscience.iop.org
Capsaicin is a bioactive phytochemical of red and chili peppers. It has shown therapeutic
properties, including anticancer activities. In this study, the potential anti-telomerase effect of …
properties, including anticancer activities. In this study, the potential anti-telomerase effect of …
Combinatorial targeting of telomerase and DNA-PK induces synergistic apoptotic effects against Pre-B acute lymphoblastic leukemia cells
M Katoueezadeh, P Maleki, SA Torabizadeh… - Molecular Biology …, 2024 - Springer
Background Due to the high demand for novel approaches for leukemia-targeted therapy,
this study investigates the impact of DNA-PK inhibitor NU7441 on the sensitivity of pre-B ALL …
this study investigates the impact of DNA-PK inhibitor NU7441 on the sensitivity of pre-B ALL …
A target-triggered fluorescence-SERS dual-signal nano-system for real-time imaging of intracellular telomerase activity
YJ Zhao, PF Shen, JH Fu, FR Yang, ZP Chen, RQ Yu - Talanta, 2024 - Elsevier
Telomerase (TE) is a promising diagnostic and prognostic biomarker for many cancers.
Quantification of TE activity in living cells is of great significance in biomedical and clinical …
Quantification of TE activity in living cells is of great significance in biomedical and clinical …
Mendelian randomization analysis reveals the combined effects of epigenetics and telomere biology in hematologic cancers
X Zhuang, P Chen, R Yang, X Man, R Wang, Y Shi - Clinical Epigenetics, 2024 - Springer
Background Telomere shortening and epigenetic modifications are key factors in aging and
hematologic diseases. This study investigates the relationship of telomere length and …
hematologic diseases. This study investigates the relationship of telomere length and …
A Label-Free, One-Step Isothermal Assay for Sensitive Detection of Telomerase Activity Using Light-Up Aptamer
H Han, JH Jeung, Y Cho, JK Ahn - BioChip Journal, 2024 - Springer
Telomerase is a critical biomarker for cancer diagnosis and therapy due to its
overexpression in tumor cells. Traditional methods for detecting telomerase activity, such as …
overexpression in tumor cells. Traditional methods for detecting telomerase activity, such as …
Cord blood stem cell-generated KIR+ NK cells effectively target leukemia cell lines
Acute lymphoid (ALL) and myeloid leukemia (AML) are known to be invasive and highly
lethal hematological malignancies. Because current treatments are insufficient and have a …
lethal hematological malignancies. Because current treatments are insufficient and have a …
Telomerase and mitochondria inhibition promote apoptosis and TET2 and ANMT3a expression in triple negative breast cancer cell lines
Introduction: High metastasis, resistance to common treatments, and high mortality rate, has
made triple-negative breast cancer (TNBC) to be the most invasive type of breast cancer …
made triple-negative breast cancer (TNBC) to be the most invasive type of breast cancer …
Bone marrow CD34 positive cells may be suitable for collection after death
Hematopoietic stem cells (HSCs) which are characterized with CD34+ phenotype, have a
pivotal role in blood cell regeneration. They are located in lowest hypoxic areas in the bone …
pivotal role in blood cell regeneration. They are located in lowest hypoxic areas in the bone …