The spatial and temporal coordination of protein transport is an essential cornerstone of the
bacterial adaptation to different environmental conditions. By adjusting the protein …

About 30% of all bacterial proteins execute their function outside of the cytosol and have to
be transported into or across the cytoplasmic membrane. Bacteria use multiple protein …

The insertion and assembly of proteins into the inner membrane of bacteria are crucial for
many cellular processes, including cellular respiration, signal transduction, and ion and pH …

Co-translational protein targeting to membranes by the signal recognition particle (SRP) is a
universally conserved pathway from bacteria to humans. In mammals, SRP and its receptor …

During co-translational protein targeting, the signal recognition particle (SRP) binds to the
translating ribosome displaying the signal sequence to deliver it to the SRP receptor (SR) on …

More than a third of all bacterial polypeptides, comprising the 'exportome', are transported to
extracytoplasmic locations. Most of the exportome is targeted and inserts into …

Small membrane proteins represent a largely unexplored yet abundant class of proteins in
pro-and eukaryotes. They essentially consist of a single transmembrane domain and are …

The SecYEG translocon constitutes the major protein transport channel in bacteria and
transfers an enormous variety of different secretory and inner-membrane proteins. The …

During synthesis of membrane proteins, transmembrane segments (TMs) of nascent
proteins emerging from the ribosome are inserted into the central pore of the translocon …

The bacterial signal recognition particle (SRP) is part of the machinery that targets
ribosomes synthesizing membrane proteins to membrane-embedded translocons co …