Epstein–Barr virus and cancer

PJ Farrell - Annual Review of Pathology: Mechanisms of …, 2019 - annualreviews.org
Epstein–Barr virus (EBV) contributes to about 1.5% of all cases of human cancer worldwide,
and viral genes are expressed in the malignant cells. EBV also very efficiently causes the …

Epstein–barr virus history and pathogenesis

H Yu, ES Robertson - Viruses, 2023 - mdpi.com
Epstein–Barr virus (EBV) is the first identified human oncogenic virus that can establish
asymptomatic life-long persistence. It is associated with a large spectrum of diseases …

Epstein-barr-virus-induced one-carbon metabolism drives B cell transformation

LW Wang, H Shen, L Nobre, I Ersing, JA Paulo… - Cell metabolism, 2019 - cell.com
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas.
How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely …

Epstein–Barr virus as a potentiator of autoimmune diseases

WH Robinson, S Younis, ZZ Love, L Steinman… - Nature Reviews …, 2024 - nature.com
Abstract The Epstein–Barr virus (EBV) is epidemiologically associated with development of
autoimmune diseases, including systemic lupus erythematosus, Sjögren syndrome …

Epstein-Barr virus oncoprotein super-enhancers control B cell growth

H Zhou, SCS Schmidt, S Jiang, B Willox, K Bernhardt… - Cell host & …, 2015 - cell.com
Super-enhancers are clusters of gene-regulatory sites bound by multiple transcription
factors that govern cell transcription, development, phenotype, and oncogenesis. By …

Mechanisms of B-cell oncogenesis induced by Epstein-Barr virus

A Saha, ES Robertson - Journal of Virology, 2019 - Am Soc Microbiol
Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus which asymptomatically infects
the majority of the world population. Under immunocompromised conditions, EBV can …

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth

B Zhao, J Zou, H Wang, E Johannsen… - Proceedings of the …, 2011 - National Acad Sciences
Epstein-Barr virus nuclear antigen 2 (EBNA2) regulation of transcription through the cell
transcription factor RBPJ is essential for resting B-lymphocyte (RBL) conversion to immortal …

The c‐myc promoter: still MysterY and challenge

I Wierstra, J Alves - Advances in cancer research, 2008 - Elsevier
The transcription factor c‐Myc is a key regulator of cell proliferation, cell growth,
differentiation, and apoptosis. Deregulated c‐myc expression possesses a high …

The Epstein-Barr virus regulome in lymphoblastoid cells

S Jiang, H Zhou, J Liang, C Gerdt, C Wang, L Ke… - Cell host & …, 2017 - cell.com
Epstein-Barr virus (EBV) transforms B cells to continuously proliferating lymphoblastoid cell
lines (LCLs), which represent an experimental model for EBV-associated cancers. EBV …

RNA sequencing analyses of gene expression during Epstein-Barr virus infection of primary B lymphocytes

C Wang, D Li, L Zhang, S Jiang, J Liang… - Journal of …, 2019 - Am Soc Microbiol
Epstein-Barr virus (EBV) infection of human primary resting B lymphocytes (RBLs) leads to
the establishment of lymphoblastoid cell lines (LCLs) that can grow indefinitely in vitro. EBV …