Emerging hallmarks of metabolic reprogramming in prostate cancer

F Lasorsa, NA di Meo, M Rutigliano, M Ferro… - International Journal of …, 2023 - mdpi.com
Prostate cancer (PCa) is the most common male malignancy and the fifth leading cause of
cancer death in men worldwide. Prostate cancer cells are characterized by a hybrid …

Fatty acid synthesis in prostate cancer: vulnerability or epiphenomenon?

LA Sena, SR Denmeade - Cancer research, 2021 - AACR
Tumor metabolism supports the energetic and biosynthetic needs of rapidly proliferating
cancer cells and modifies intra-and intercellular signaling to enhance cancer cell invasion …

A multimodal atlas of tumour metabolism reveals the architecture of gene–metabolite covariation

E Benedetti, EM Liu, C Tang, F Kuo, M Buyukozkan… - Nature …, 2023 - nature.com
Tumour metabolism is controlled by coordinated changes in metabolite abundance and
gene expression, but simultaneous quantification of metabolites and transcripts in primary …

The prostate cancer androgen receptor cistrome in African American men associates with upregulation of lipid metabolism and immune response

JE Berchuck, E Adib, S Abou Alaiwi, AK Dash, JN Shin… - Cancer research, 2022 - AACR
African-American (AA) men are more likely to be diagnosed with and die from prostate
cancer than European American (EA) men. Despite the central role of the androgen receptor …

A comparison of different machine-learning techniques for the selection of a panel of metabolites allowing early detection of brain tumors

A Godlewski, M Czajkowski, P Mojsak, T Pienkowski… - Scientific Reports, 2023 - nature.com
Metabolomics combined with machine learning methods (MLMs), is a powerful tool for
searching novel diagnostic panels. This study was intended to use targeted plasma …

Circulating cell-free DNA in renal cell carcinoma: the new era of precision medicine

E Francini, GN Fanelli, F Pederzoli, S Spisak… - Cancers, 2022 - mdpi.com
Simple Summary Early diagnosis of renal cell carcinoma (RCC) is challenging and typically
incidental. Currently, several therapeutic strategies are used for the treatment; however, no …

The prognostic impact of gender, therapeutic strategies, molecular background, and tumor-infiltrating lymphocytes in glioblastoma: a still unsolved jigsaw

L Innocenti, V Ortenzi, R Scarpitta, N Montemurro… - Genes, 2023 - mdpi.com
Despite the adoption of novel therapeutical approaches, the outcomes for glioblastoma
(GBM) patients remain poor. In the present study, we investigated the prognostic impact of …

Plasma metabolomics for discovery of early metabolic markers of prostate cancer based on ultra-high-performance liquid chromatography-high resolution mass …

X Lin, L Lécuyer, X Liu, MN Triba… - Cancers, 2021 - mdpi.com
Simple Summary Correct identification of subjects at high risk is critical in the prevention and
early screening of prostate cancer (PCa). Analysis of metabolites in biofluids has shown to …

Multimodal convolutional neural networks based on the Raman spectra of serum and clinical features for the early diagnosis of prostate cancer

Y Wang, H Qian, X Shao, H Zhang, S Liu, J Pan… - … Acta Part A: Molecular …, 2023 - Elsevier
We collected surface-enhanced Raman spectroscopy (SERS) data from the serum of 729
patients with prostate cancer or benign prostatic hyperplasia (BPH), corresponding to their …

Mechanisms of prostate cancer cells survival and their therapeutic targeting

T Pejčić, Z Todorović, S Đurašević… - International Journal of …, 2023 - mdpi.com
Prostate cancer (PCa) is today the second most common cancer in the world, with almost
400,000 deaths annually. Multiple factors are involved in the etiology of PCa, such as older …