Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …

The first full publications on the biological effects of the diphosphonates, later renamed
bisphosphonates, appeared in 1969, so it is timely after 40 years to review the history of their …

Cardiovascular complications due to accelerated arterial stiffening and atherosclerosis are
the leading cause of morbimortality in Western society. Both pathologies are frequently …

Objective—Mutations in ABCC6 underlie the ectopic mineralization disorder
pseudoxanthoma elasticum (PXE) and some forms of generalized arterial calcification of …

The process of aging is associated with the appearance of low-grade subclinical
inflammation, termed inflammaging, that can accelerate age-related diseases. In Western …

Table of contents: I. Structure and function of joints, connective tissue, and muscle. II.
Immune and inflammatory responses. III. Evaluation of the patient. IV. Special issues of the …

Extracellular matrix (ECM) mineralization is a physiological process in bone and a
pathological one in soft tissues. The mechanisms determining the spatial restriction of ECM …

The discovery and development of the bisphosphonates (BPs) as a major class of drugs for
the treatment of bone diseases has been a fascinating journey that is still not over. In clinical …

The analysis of rare genetic disorders affecting phosphate homeostasis led to the
identification of several proteins that are essential for the renal regulation of phosphate …

The bisphosphonates (BPs) are well established as the treatments of choice for disorders of
excessive bone resorption, including Paget's disease of bone, myeloma and bone …