Sudden death in schizophrenia

KJ Li, AP Greenstein, LE Delisi - Current opinion in psychiatry, 2018 - journals.lww.com
There is a huge paucity in genetic and pharmacogenetic data focused on SUD in
schizophrenia. Future studies should emphasize the genetic aspects as well as clarify the …

Potentially fatal outcomes associated with clozapine

KJ Li, RJ Gurrera, LE Delisi - Schizophrenia Research, 2018 - Elsevier
Clozapine has been shown to be the most efficacious therapy for treatment resistant
schizophrenia, estimated at one third of all schizophrenia cases. There is significant …

Clozapine-induced myocarditis: electronic health register analysis of incidence, timing, clinical markers and diagnostic accuracy

A Segev, E Iqbal, TA McDonagh, C Casetta… - The British journal of …, 2021 - cambridge.org
BackgroundClozapine is associated with increased risk of myocarditis. However, many
common side-effects of clozapine overlap with the clinical manifestations of myocarditis. As …

[HTML][HTML] Atypical antipsychotics and oxidative cardiotoxicity: review of literature and future perspectives to prevent sudden cardiac death

S D'Errico, R La Russa, A Maiese… - Journal of Geriatric …, 2021 - ncbi.nlm.nih.gov
Oxidative stress is considered the principal mediator of myocardial injury under pathological
conditions. It is well known that reactive oxygen (ROS) or nitrogen species (RNS) are …

Clozapine-induced myocarditis: pathophysiologic mechanisms and implications for therapeutic approaches

SW Rabkin, JKK Tang - Current Molecular Pharmacology, 2023 - benthamdirect.com
Clozapine, a superior treatment for treatment-resistant schizophrenia can cause potentially
life-threatening myocarditis and dilated cardiomyopathy. While the occurrence of this …

Clozapine: mechanisms of toxicity and side effects

AS Babkina, AM Golubev, DV Sundukov… - General …, 2018 - reanimatology.com
Clozapine is an atypical antipsychotic agent with a confirmed effectiveness which is widely
used in the clinical practice. However, its administration is associated with a high risk of …

Клозапин: механизмы токсичности и побочных эффектов

АС Бабкина, АМ Голубев, ДВ Сундуков… - Общая …, 2018 - cyberleninka.ru
Клозапин–атипичное антипсихотическое средство с доказанной эффективностью,
которое широко используется в клинической практике. Однако, его применение …

[HTML][HTML] The autopsy as the cornerstone for education and research in cardiology

VD Aiello - Autopsy & case reports, 2016 - ncbi.nlm.nih.gov
In the era of advanced techniques of medical imaging, it is becoming increasingly difficult to
support the role of the traditional autopsy in the diagnosis of diseases, including those of the …

[HTML][HTML] Profile of clozapine therapy: a cross sectional piloting in a tertiary care setting of Bangladesh

MS Uddin, S Ahmed, SMY Arafat - Journal of Psychiatry and …, 2017 - fortuneonline.org
Clozapine is a very important atypical antipsychotic indicated for one to two third patients of
resistant psychotic symptoms. It is also indicated in Treatment Resistant Bipolar Disorder …

Differential DNA Methylation and Gene Expression in Stem Cell-Derived Cardiomyocytes from Patients with and without a History of Clozapine-Induced Myocarditis.

C Bousman, D Marques, L Spíndola, A Narang… - 2024 - researchsquare.com
Clozapine is an effective antipsychotic medication for the management of treatment-resistant
schizophrenia. However, the use of clozapine is limited due to severe and sometimes fatal …