We discuss how small-molecule inhibitors of the tryptophan (Trp) catabolic enzyme
indoleamine 2, 3-dioxygenase (IDO) represent a vanguard of new immunometabolic …

There is growing evidence that metabolic alterations play an important role in cancer
development and progression. The metabolism of cancer cells is reprogrammed in order to …

Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32
recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH …

This book is the third volume of the 4th Edition of the WHO series on histological and genetic
typing of human tumours. It is an authoritative, concise reference book providing an …

Pancreatic cancer expression profiles largely reflect a classical or basal-like phenotype. The
extent to which these profiles vary within a patient is unknown. We integrated evolutionary …

Abstract Changes of radiomic features over time in longitudinal images, delta radiomics, can
potentially be used as a biomarker to predict treatment response. This study aims to develop …

Cancer is fundamentally a genetic disease caused by the accumulation of somatic mutations
in oncogenes and tumor suppressor genes. In the last decade, rapid advances in …

Pancreatic adenocarcinoma is one of the deadliest malignancies worldwide, mainly due to
frequent diagnosis at an advanced stage and its strong chemoresistance. Tumor …

Pancreatic adenosquamous carcinoma (ASC) is an enigmatic and aggressive tumor that
has a worse prognosis and higher metastatic potential than its adenocarcinoma counterpart …

Context.—The introduction of genome-and epigenome-wide screening techniques has
dramatically improved our understanding of the molecular mechanisms underlying the …