Multiple mechanisms mediate thrombin generation and consequently the thrombin
concentration present during fibrin formation. First, the levels of pro-and anticoagulants …

Blood platelets have long been recognised to bring about primary haemostasis with
deficiencies in platelet production and function manifesting in bleeding while upregulated …

Research on all stages of fibrin polymerization, using a variety of approaches including
naturally occurring and recombinant variants of fibrinogen, x-ray crystallography, electron …

The coagulopathy of acute sepsis : Current Opinion in Anesthesiology The coagulopathy of
acute sepsis : Current Opinion in Anesthesiology Log in or Register Subscribe to journalSubscribe …

The formation of fibrin clots that are relatively resistant to lysis represents the final step in
blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in …

Virchow's triad is traditionally invoked to explain pathophysiologic mechanisms leading to
thrombosis, alleging concerted roles for abnormalities in blood composition, vessel wall …

Vascular regeneration and patency maintenance, without anticoagulant administration,
represent key developmental trends to enhance small-diameter vascular grafts (SDVG) …

Sepsis is often associated with haemostatic changes ranging from subclinical activation of
blood coagulation (hypercoagulability), which may contribute to localized venous …

Sepsis, a medical emergency, is the overwhelming host response to infection leading to
organ failure. The pathophysiology of this heterogeneous disease includes an inflammatory …

As platelets aggregate and activate at the site of vascular injury to stem bleeding, they are
subjected to a myriad of biochemical and biophysical signals and cues. As clot formation …