Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Cardiovascular disease in dialysis patients

M Cozzolino, M Mangano, A Stucchi… - Nephrology Dialysis …, 2018 - academic.oup.com
Cardiovascular disease (CVD) is a highly common complication and the first cause of death
in patients with end-stage renal disease (ESRD) on haemodialysis (HD). In this population …

A reference map of potential determinants for the human serum metabolome

N Bar, T Korem, O Weissbrod, D Zeevi, D Rothschild… - Nature, 2020 - nature.com
The serum metabolome contains a plethora of biomarkers and causative agents of various
diseases, some of which are endogenously produced and some that have been taken up …

Beneficial effects of dietary polyphenols on gut microbiota and strategies to improve delivery efficiency

A Kumar Singh, C Cabral, R Kumar, R Ganguly… - Nutrients, 2019 - mdpi.com
The human intestine contains an intricate ecological community of dwelling bacteria,
referred as gut microbiota (GM), which plays a pivotal role in host homeostasis. Multiple …

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

D Mafra, NA Borges, B Lindholm, PG Shiels… - Nature Reviews …, 2021 - nature.com
The observation that unhealthy diets (those that are low in whole grains, fruits and
vegetables, and high in sugar, salt, saturated fat and ultra-processed foods) are a major risk …

High-coverage metabolomics uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication in mice

Y Lai, CW Liu, Y Yang, YC Hsiao, H Ru, K Lu - Nature communications, 2021 - nature.com
The mammalian gut harbors a complex and dynamic microbial ecosystem: the microbiota.
While emerging studies support that microbiota regulates brain function with a few molecular …

Dysbiosis of the gut microbiota in disease

S Carding, K Verbeke, DT Vipond… - Microbial ecology in …, 2015 - Taylor & Francis
There is growing evidence that dysbiosis of the gut microbiota is associated with the
pathogenesis of both intestinal and extra-intestinal disorders. Intestinal disorders include …

The microbiome of the urinary tract—a role beyond infection

SA Whiteside, H Razvi, S Dave, G Reid… - Nature Reviews …, 2015 - nature.com
Urologists rarely need to consider bacteria beyond their role in infectious disease. However,
emerging evidence shows that the microorganisms inhabiting many sites of the body …

Alzheimer's disease and gut microbiota

X Hu, T Wang, F Jin - Science China Life Sciences, 2016 - Springer
Alzheimer's disease (AD) is a most common neurodegenerative disorder, which associates
with impaired cognition. Gut microbiota can modulate host brain function and behavior via …

The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review

R Vanholder, E Schepers, A Pletinck… - Journal of the …, 2014 - journals.lww.com
A growing number of publications supports a biologic effect of the protein-bound uremic
retention solutes indoxyl sulfate and p-cresyl sulfate. However, the use of unrealistically high …