Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Stem cells are rare and unique precursor cells that participate in the building and rebuilding
of tissues and organs during embryogenesis, postnatal growth, and injury repair. Stem cells …

PTPN2 (protein tyrosine phosphatase non-receptor type 2, also known as TC-PTP) is a
cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine …

The identification of activating mutations in NOTCH1 in over 50% of T-cell acute
lymphoblastic leukemias (T-ALL) has generated major interest in the elucidation of the …

Aberrant regulation of Notch signaling has been implicated in tumorigenesis. Proteolytic
release of the Notch intracellular domain (NICD) by γ-secretase plays a key role in Notch …

Given the high frequency of activating NOTCH1 mutations in T cell acute lymphoblastic
leukemia (T-ALL), inhibition of the γ-secretase complex remains an attractive target to …

Proteolytic resistance of Notch prior to ligand binding depends on the structural integrity of a
negative regulatory region (NRR) of the receptor that immediately precedes the …

Abstract Purpose of Review Patients with relapsed T cell acute lymphoblastic leukemia (T-
ALL) have limited therapeutic options and a poor prognosis. Although a variety of salvage …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor resulting
from the malignant transformation of immature T-cell progenitors. Originally associated with …

Dysregulated Notch signaling has been implicated in numerous human diseases, including
a broad spectrum of cancers. Mutations in Notch1 are prevalent in T-cell acute lymphoblastic …