The neural circuits underlying the distinct endpoints that define general anesthesia remain
incompletely understood. It is becoming increasingly evident, however, that distinct …

By identifying endogenous molecules in brain extracellular fluid metabolomics can provide
insight into the regulatory mechanisms and functions of sleep. Here we studied how the …

This study quantified eight small-molecule neurotransmitters collected simultaneously from
prefrontal cortex of C57BL/6J mice (n= 23) during wakefulness and during isoflurane …

We review evidence challenging the hypothesis that memories are processed or
consolidated in sleep. We argue that the brain is in an unconscious state in sleep, akin to …

Identifying similarities and differences in the brain metabolome during different states of
consciousness has broad relevance for neuroscience and state-dependent autonomic …