It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Centrioles are microtubule-based core components of centrosomes and cilia. They are
duplicated exactly once during S-phase progression. Central to formation of each new …

The mTORC1 (mechanistic target of rapamycin complex 1) protein kinase regulates growth
in response to nutrients and growth factors. Nutrients promote its translocation to the …

Autosomal recessive primary microcephaly (MCPH;“small head syndrome”) is a rare,
heterogeneous disease arising from the decreased production of neurons during brain …

During animal development, embryos undergo complex morphological changes over time.
Differences in developmental tempo between species are emerging as principal drivers of …

Mitotic cell divisions increase cell number while faithfully distributing the replicated genome
at each division. The Caenorhabditis elegans embryo is a powerful model for eukaryotic cell …

Plasmodium falciparum is the most lethal of human-infective malaria parasites. A hallmark of
P. falciparum malaria is extensive remodeling of host erythrocytes by the parasite, which …

Centrioles are evolutionarily conserved barrels of microtubule triplets that form the core of
the centrosome and the base of the cilium. While the crucial role of the proximal region in …

Sas-6 and Ana2/STIL proteins are required for centriole duplication and the homo-
oligomerisation properties of Sas-6 help establish the ninefold symmetry of the central …

MicroCephaly Primary Hereditary (MCPH) is a rare congenital neurodevelopmental disorder
characterized by a significant reduction of the occipitofrontal head circumference and mild to …