Tumor-bearing experimental animals are essential for preclinical cancer drug development.
A broad range of tumor models is available, with the simplest and most widely used …

Receptor tyrosine kinases are often aberrantly activated in human malignancies and
contribute to cancer development and progression. Specific receptor tyrosine kinase …

In this study, we characterized the significance of the vascular endothelial growth factor-
inducible angiogenesis inhibitor vasohibin-1 to tumors. In pathological sections of non-small …

Cisplatin is an extensively used chemotherapeutic drug for lung cancer, but the
development of resistance decreases its effectiveness in the treatments of non-small cell …

The MET tyrosine kinase receptor is a high-affinity receptor for hepatocyte growth
factor/scatter factor (HGF/SF). HGF/SF-MET system is necessary for embryonic development …

The hepatocyte growth factor (HGF) also known as scatter factor activates cancer cell
invasion and metastasis. We show that in ovarian cancer cells HGF induced the …

Purpose: The aim of the study was to verify the hypothesis that the cMet oncogene is
implicated in chemio-and novel drug resistance in multiple myeloma. Experimental Design …

The small heat‐shock protein of 27 kDa (HSP 27) is highly expressed in many cancers and
is associated with aggressive tumour behaviour, metastasis, poor prognosis and resistance …

The c‐MET receptor tyrosine kinase is the receptor for hepatocyte growth factor. Recently,
activation of the c‐MET/hepatocyte growth factor signaling pathway was associated with …

Ovarian cancer is the most lethal gynecologic malignancy. Recently, NACT (Neo Adjuvant
Chemotherapy) has been tested as alternative approach for the management of ovarian …