Over a half a century of research has confirmed that neurotrophic factors promote the
survival and process outgrowth of isolated neurons in vitro. The mechanisms by which …

Several new members of the nerve growth factor family of neurotrophins, which comprises
nerve growth factor itself, brain-derived neurotrophic factor and neurotrophins-3,-4 (also …

Brain-derived neurotrophic factor (BDNF), a neurotrophin, enhances the survival and
differentiation of several classes of neurons in vitro. To determine fts esaential functions, we …

Brain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase
B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and …

Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as
cell differentiation and survival, growth cessation and apoptosis of neurons. These events …

Receptor tyrosine kinases (RTKs) play essential roles in cellular processes, including
metabolism, cell-cycle control, survival, proliferation, motility and differentiation. RTKs are all …

The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons, and have since been shown to control a …

The role of the low affinity neurotrophin receptor, p75LNT', in NGF-mediated signal
transduction has been examined. Our results show that treatment of PC12 cells with MC192 …

Nerve growth factor (NGF) binds to two cell surface receptors, p140trk and p75NGFR, which
are both expressed in responsive sensory, sympathetic, and basal forebrain cholinergic …

Neurotrophins are critical for the development and maintenance of the peripheral and
central nervous system. These highly homologous, homodimeric growth factors control cell …