Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

Population aging is an irreversible global trend with economic and socio-political
consequences. One of the most invalidating outcomes of aging in the elderly is cognitive …

The fusion of machine learning (ML) and artificial intelligence (AI) is experiencing a dramatic
transition in the field of pharmaceutical research and development. This study examines the …

Several findings propose the altered tau protein network as an important target for
Alzheimer's disease (AD). Particularly, two points of pharmacological intervention can be …

Two of the most common neurodegenerative disorders–Alzheimer's and Parkinson's
diseases–are characterized by synaptic dysfunction and degeneration that culminate in …

Notwithstanding the combination of cholinesterase (ChE) inhibition and calcium channel
blockade within a multitarget therapeutic approach is envisaged as potentially beneficial to …

Alzheimer's disease (AD) is a complex neurodegenerative disorder with a multifaceted
pathogenesis. This fact has long halted the development of effective anti-AD drugs …

Restoring the compromised neurogenesis has been served as a potential strategy to rescue
cognitive dysfunction of Alzheimer's disease (AD). In this study, we explored whether icarisid …

During the last decade, the one drug-one target strategy has resulted to be inefficient in
facing diseases with complex ethiology like Alzheimer's disease and many others. In this …

Ethnopharmacological relevance According to the theory of traditional Chinese medicine
(TCM), Alzheimer's disease (AD) is identified as “forgetfulness” or “dementia”, and is mainly …