The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Endothelial cells line blood vessels and provide a dynamic interface between the blood and
tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during …

There are inherent limitations with traditional methods to study protein behavior or to
determine the constituency of proteins in discrete subcellular compartments. In response to …

The endothelial barrier consists of intercellular contacts localized in the cleft between
endothelial cells, which is covered by the glycocalyx in a sievelike manner. Both types of …

The Rho family of small GTPases orchestrates fundamental biological processes such as
cell cycle progression, cell migration, and actin cytoskeleton dynamics, and their aberrant …

The Rho subfamily members of Rho GTPases, RhoA, RhoB, and RhoC, are key regulators
of signal transduction in a variety of cellular processes, including regulation of actomyosin …

RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct
functions in cells. Its unique C-terminal region is subject to specific post-translational …

Objective: The goal of this article was to identify potential biomarkers for early diagnosis of
sepsis in order to improve their survival. Methods: We analyzed differential gene expression …

BACKGROUND: Systemic inflammatory diseases, such as sepsis and severe COVID-19,
provoke acute respiratory distress syndrome in which the pathological hyperpermeability of …

Although Rho GTPases RhoA, RhoB, and RhoC share more than 85% amino acid
sequence identity, they play very distinct roles in tumor progression. RhoA and RhoC have …