Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan

Z Papp, I Édes, S Fruhwald, SG De Hert… - International journal of …, 2012 - Elsevier
The molecular background of the Ca2+-sensitizing effect of levosimendan relates to its
specific interaction with the Ca2+-sensor troponin C molecule in the cardiac myofilaments …

The protective effects of levosimendan on ischemia/reperfusion injury and apoptosis

P Scheiermann, A Beiras-Fernandez… - Recent Patents on …, 2011 - ingentaconnect.com
Levosimendan is a calcium sensitizer with positive inotropic and vasodilating properties. It
increases the sensitivity of troponin C for calcium, opens adenosine triphosphate-dependent …

Levosimendan protects human hepatocytes from ischemia-reperfusion injury

SN Brunner, NV Bogert, AA Schnitzbauer, E Juengel… - PLoS …, 2017 - journals.plos.org
Background Ischemia-reperfusion injury (IRI) is a major challenge in liver transplantation.
The mitochondrial pathway plays a pivotal role in hepatic IRI. Levosimendan, a calcium …

The coadministration of levosimendan and exenatide offers a significant cardioprotective effect to isolated rat hearts against ischemia/reperfusion injury

V Leivaditis, E Koletsis, N Tsopanoglou… - Journal of …, 2022 - mdpi.com
(1) Background: The present study aims to investigate the effect of administration of
Levosimendan and Exenatide in various concentrations, as well as of the coadministration …

Piperphentonamine (PPTA) attenuated cerebral ischemia-induced memory deficits via neuroprotection associated with anti-apoptotic activity

J Bin, Q Wang, YY Zhuo, JP Xu, HT Zhang - Metabolic brain disease, 2012 - Springer
The calcium sensitizers levosimendan and piperphentonamine hydrochloride (PPTA) are
used as cardiovascular drugs for treatment of heart failure. Given that levosimendan has …

Levosimendan reduces lung injury in a canine model of cardiopulmonary bypass

J Feng, H Liu, J Chen, J Wang… - Korean Circulation …, 2016 - synapse.koreamed.org
Background and Objectives To explore the lung-protective effect of levosimendan (LS)
during cardiopulmonary bypass in a canine model by determining the wet/dry weight (W/D) …

Intracoronary levosimendan during ischemia prevents myocardial apoptosis

M Malmberg, T Vähäsilta, A Saraste… - Frontiers in …, 2012 - frontiersin.org
Background: Levosimendan is a calcium sensitizer that has been shown to prevent
myocardial contractile depression in patients post cardiac surgery. This drug exhibits an anti …

The role of Levosimendan in cardiopulmonary resuscitation

G Varvarousi, A Stefaniotou, D Varvaroussis… - European Journal of …, 2014 - Elsevier
Although initial resuscitation from cardiac arrest (CA) has increased over the past years,
long term survival rates remain dismal. Epinephrine is the vasopressor of choice in the …

[HTML][HTML] Cardiopulmonary bypass, inflammation and how to defy it: focus on pharmacological interventions

A Dabbagh, S Rajaei, AB Monfared… - Iranian journal of …, 2012 - ncbi.nlm.nih.gov
One of the most common health problems are diseases of the cardiovascular system with a
great bulk of disease burden; while a considerable number of cardiac patients undergo …

Effects of the addition of endotoxin during perfusion of isolated forelimbs of equine cadavers

B Patan-Zugaj, FC Gauff, TF Licka - American journal of …, 2012 - Am Vet Med Assoc
Objective—To examine the effect of endotoxins on metabolism and histopathologic changes
of isolated perfused equine forelimbs. Sample—Forelimbs (comprising the metacarpus and …