Filariasis is one of the oldest, most debilitating, disabling, and disfiguring neglected tropical
diseases with various clinical manifestations and a low rate of mortality, but has a high …

First synthesis of novel coumarin–trioxane hybrids is reported. The synthesis was achieved
via condensation of β-hydroxyhydroperoxides with coumarinic-aldehydes in presence of p …

In the last 2 decades, renewed attention to neglected tropical diseases (NTDs) has spurred
the development of antiparasitic agents, especially in light of emerging drug resistance. The …

Here we report the synthesis of novel chalcone–thiazole compounds and their antifilarial
activity. The antifilarial properties of these hybrids were assessed against microfilariae as …

In our continuing search for safe and efficacious antifilarials, a series of novel chalcone-
benzothiazole hybrids have been synthesized and evaluated for their Brugia malayi …

Lymphatic filariasis continues to be a major health problem in tropical and subtropical
countries. A macrofilaricidal agent capable of eliminating adult filarial parasites is urgently …

A series of 4-oxycoumarin derivatives was synthesized, characterized and evaluated in vitro
and in vivo for antifilarial activity against the human lymphatic filarial parasite, Brugia malayi …

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Background Lymphatic filariasis caused by Wuchereria bancrofti, Brugia malayi and B.
timori, is a debilitating disease with an adverse social and economic impact. The infection …

Background: Lymphatic filariasis (LF) is a parasitic disease that causes permanent disability
(elephantiasis). Currently used antifilarial drugs are failing to control LF and there is …