Single-cell RNA sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …

Parkinson's disease (PD) is a neurodegenerative disorder caused by a complex interplay of
genetic and environmental factors. For the stratification of PD patients and the development …

Context In the last decade, genome-wide association studies (GWASs) have catalyzed our
understanding of the genetics of height and have identified hundreds of regions of the …

During human evolution, the knee adapted to the biomechanical demands of bipedalism by
altering chondrocyte developmental programs. This adaptive process was likely not without …

Evolutionary responses to selection for bipedalism and childbirth have shaped the human
pelvis, a structure that differs substantially from that in apes. Morphology related to these …

It is important to study the genetics of complex traits in diverse populations. Here, we
introduce covariate-adjusted linkage disequilibrium (LD) score regression (cov-LDSC), a …

Given the pleiotropic nature of coding sequences and that many loci exhibit multiple disease
associations, it is within non-coding sequence that disease-specificity likely exists. Here, we …

The mechanical challenge of attaching elastic tendons to stiff bones is solved by the
formation of a unique transitional tissue. Here, we show that murine tendon-to-bone …

To address large gaps in our understanding of the molecular regulation of articular and
growth plate cartilage development in humans, we used our directed differentiation …

Despite the great diversity of vertebrate limb proportion and our deep understanding of the
genetic mechanisms that drive skeletal elongation, little is known about how individual …