Vesicle trafficking pathways in defence-related cell wall modifications-papillae and encasements

ME Nielsen - Journal of Experimental Botany, 2024 - academic.oup.com
Filamentous pathogens that cause plant diseases such as powdery mildew, rust,
anthracnose, and late blight continue to represent an enormous challenge for farmers …

Phosphoinositide switches in cell physiology-From molecular mechanisms to disease

F Lolicato, W Nickel, V Haucke, M Ebner - Journal of Biological Chemistry, 2024 - ASBMB
Phosphoinositides are amphipathic lipid molecules derived from phosphatidylinositol that
represent low abundance components of biological membranes. Rather than serving as …

Endocytosis blocks the vesicular secretion of exosome marker proteins

Y Ai, C Guo, M Garcia-Contreras, LS Sánchez B… - Science …, 2024 - science.org
Exosomes are secreted vesicles of~ 30 to 150 nm diameter that play important roles in
human health and disease. To better understand how cells release these vesicles, we …

The endolysosomal system in conventional and unconventional protein secretion

E Néel, M Chiritoiu-Butnaru, W Fargues… - Journal of Cell …, 2024 - rupress.org
Most secreted proteins are transported through the “conventional” endoplasmic reticulum–
Golgi apparatus exocytic route for their delivery to the cell surface and release into the …

Nutrient signaling: Starvation flips a phosphoinositide switch on lysosomal catabolism

MJ Nagiec, J Blenis - Current Biology, 2023 - cell.com
Nutrient signaling: Starvation flips a phosphoinositide switch on lysosomal catabolism:
Current Biology Skip to Main Content Advertisement Current Biology This journal offers …

The 8‐oxoguanine DNA glycosylase‐synaptotagmin 7 pathway increases extracellular vesicle release and promotes tumour metastasis during oxidative stress

Y Ma, J Guo, H Rao, J Xin, X Song, R Liu… - Journal of …, 2024 - Wiley Online Library
Reactive oxygen species (ROS)‐induced oxidative DNA damages have been considered
the main cause of mutations in genes, which are highly related to carcinogenesis and …

Asymmetric tethering by exocyst in vitro requires a Rab GTPase, an R-SNARE and a Sac1-sensitive phosphoinositide lipid

G Rossi, GC Puller, P Brennwald - Molecular Biology of the Cell, 2024 - Am Soc Cell Biol
Tethering factors play a critical role in deciphering the correct combination of vesicle and
target membrane, before SNARE complex formation and membrane fusion. The exocyst …

Extracellular vesicles in cancer therapy: Roles, potential application, and challenges

T Liu, L Sun, Y Ji, W Zhu - Biochimica et Biophysica Acta (BBA)-Reviews …, 2024 - Elsevier
Extracellular vesicles (EVs) have emerged as a novel cell-free strategy for the treatment of
many diseases including cancer as they play important roles in cancer development and …

Plasma-derived exosome miR-10a-5p promotes premature ovarian failure by target BDNF via the TrkB/Akt/mTOR signaling pathway

Z Bao, J Li, J Cai, S Yao, N Yang, J Yang… - International Journal of …, 2024 - Elsevier
Premature ovarian failure (POF) is characterized by a significant decline in the ovarian
follicle pool and oocyte reserve, alongside an increase in the number of low-quality oocytes …

[HTML][HTML] sRNA binding protein RALY facilitates colorectal cancer metastasis via enhancing exosome biogenesis in m6A dependent manner

J Zhou, L Li, Y Han, G Ge, Q Ji, H Li - International Journal of Biological …, 2024 - Elsevier
Tumor metastasis is the leading cause of cancer-related death in patients with colorectal
cancer (CRC). Heterogeneous nuclear ribonucleoproteins (hnRNPs) are RNA-binding …