PT-Finder: A multi-modal neural network approach to target identification
Efficient target identification for bioactive compounds, including novel synthetic analogs, is
crucial for accelerating the drug discovery pipeline. However, the process of target …
crucial for accelerating the drug discovery pipeline. However, the process of target …
[HTML][HTML] Synthesis, antitumor Activity, antimicrobial evaluation and molecular docking studies of some Hydrazone, 1, 3, 4-Oxadiazole, 1, 2, 4-Triazole and pyrazole …
In this study, we synthesized a number of new intriguing azoles bearing nicotinoyl moiety,
their antimicrobial and antitumor activities were investigated as well. We succeeded to …
their antimicrobial and antitumor activities were investigated as well. We succeeded to …
A Novel Na(I) Coordination Complex with s-Triazine Pincer Ligand: Synthesis, X-ray Structure, Hirshfeld Analysis, and Antimicrobial Activity
The pincer ligand 2, 4-bis (3, 5-dimethyl-1 H-pyrazol-1-yl)-6-methoxy-1, 3, 5-triazine (bpmt)
was used to synthesize the novel [Na (bpmt) 2][AuCl4] complex through the self-assembly …
was used to synthesize the novel [Na (bpmt) 2][AuCl4] complex through the self-assembly …
Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells
Abstract A series of 36 pyrazol-4-yl pyridine derivatives (8a-i, 9a-i, 10a-i, and 11a-i) was
designed, synthesized, and evaluated for its antiproliferative activity over NCI-60 cancer cell …
designed, synthesized, and evaluated for its antiproliferative activity over NCI-60 cancer cell …
Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting …
H Mousavi, M Rimaz, B Zeynizadeh - ACS Chemical …, 2024 - ACS Publications
Neurodegenerative diseases (NDs) are one of the prominent health challenges facing
contemporary society, and many efforts have been made to overcome and (or) control it. In …
contemporary society, and many efforts have been made to overcome and (or) control it. In …
Thioacetalation and Multi-Component Thiomethylative Friedel-Crafts Arylation Using BF3SMe2
M Söderström, C Matt, LR Odell - ACS omega, 2023 - ACS Publications
Herein, a method for thioacetalation using BF3SMe2 is presented. The method allows for
convenient and odor-free transformation of aldehydes to methyl-dithioacetals, a simple but …
convenient and odor-free transformation of aldehydes to methyl-dithioacetals, a simple but …
C1 Building Blocks: New Approaches for Thiomethylations and Esterification
M Söderström - 2023 - diva-portal.org
Esterification. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty
of Pharmacy 343. 113 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-1962 …
of Pharmacy 343. 113 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-1962 …