Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

One major role of the eukaryotic peptidic post-translational modifier SUMO in the cell is
transcriptional control. This occurs via modification of virtually all classes of transcriptional …

The human transcriptome contains thousands of small open reading frames (sORFs) that
encode microproteins whose functions remain largely unexplored. Here, we show that …

Genotoxicants have been used for decades as front-line therapies against cancer on the
basis of their DNA-damaging actions. However, some of their non-DNA-damaging effects …

Transcription factor (TF)-induced reprogramming of somatic cells across lineages and to
induced pluripotent stem cells (iPSCs) has revealed a remarkable plasticity of differentiated …

Embryonic stem cells possess the remarkable ability to self-organize into blastocyst-like
structures upon induction. These stem cell-based embryo models serve as invaluable …

The fidelity of the early embryonic program is underlined by tight regulation of the chromatin.
Yet, how the chromatin is organized to prohibit the reversal of the developmental program …

SUMOylation is a post-translational modification that has emerged in recent decades as a
mechanism involved in controlling diverse physiological processes and that is essential in …

Membrane-less organelles are condensates formed by phase separation whose functions
often remain enigmatic. Upon oxidative stress, PML scaffolds Nuclear Bodies (NBs) to …

Recent advances in synthetic embryology have opened new avenues for understanding the
complex events controlling mammalian peri-implantation development. Here, we show that …