We describe the development and potential use of various designs of recombinant HIV‐1
envelope glycoprotein trimers that mimic the structure of the virion‐associated spike, which …

Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …

The envelope glycoprotein trimer (Env) on the surface of HIV-1 recognizes CD4+ T cells and
mediates viral entry. During this process, Env undergoes substantial conformational …

Summary The HIV-1-envelope (Env) trimer is covered by a glycan shield of∼ 90 N-linked
oligosaccharides, which comprises roughly half its mass and is a key component of HIV …

The envelope glycoprotein trimer mediates HIV-1 entry into cells. The trimer is flexible,
fluctuating between closed and more open conformations and sometimes sampling the fully …

INTRODUCTION A major goal of HIV-1 vaccine development is to identify immunogens
capable of inducing protective titers of broadly neutralizing antibodies (bNAbs) against …

Abstract HIV-1 envelope glycoprotein (Env) is the sole target for broadly neutralizing
antibodies (bnAbs) and the focus for design of an antibody-based HIV vaccine. The Env …

For many enveloped viruses, binding to a receptor (s) on a host cell acts as the first step in a
series of events culminating in fusion with the host cell membrane and transfer of genetic …

HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing
antibodies. However, Env structure and organization in its native virion context has eluded …