Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

Osteoarthritis (OA) is the most prevalent chronic rheumatic diseases worldwide, with a
strong impact on individual and population health. OA is a clinically heterogeneous disease …

Osteoarthritis is a common complex disease imposing a large public-health burden. Here,
we performed a genome-wide association study for osteoarthritis, using data across 16.5 …

Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …

Mesenchymal stem cell (MSC) therapies have been used as cell-based treatments for
decades, owing to their anti-inflammatory, immunomodulatory, and regenerative properties …

Osteoarthritis has a highly negative impact on quality of life because of the associated pain
and loss of joint function. Here we describe the largest meta-analysis so far of osteoarthritis …

Translational genomics aims to improve human health by building on discoveries made
through genetics research and applying them in the clinical setting. This progress has been …

Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …

Although osteoarthritis (OA) aetiology is complex, genetic, genomic and epigenetic studies
published within the last decade have advanced our understanding of the molecular …

During human evolution, the knee adapted to the biomechanical demands of bipedalism by
altering chondrocyte developmental programs. This adaptive process was likely not without …