T cell receptor (TCR) signaling in health and disease
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
Coreceptors and TCR signaling–the strong and the weak of it
The T-cell coreceptors CD4 and CD8 have well-characterized and essential roles in thymic
development, but how they contribute to immune responses in the periphery is unclear …
development, but how they contribute to immune responses in the periphery is unclear …
Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling
INTRODUCTION T cell receptor (TCR) recognition of peptide–major histocompatibility
complexes (pMHCs) is one of the most diverse receptor–ligand interactions in biology …
complexes (pMHCs) is one of the most diverse receptor–ligand interactions in biology …
Self-programmed dynamics of T cell receptor condensation
A common event upon receptor–ligand engagement is the formation of receptor clusters on
the cell surface, in which signaling molecules are specifically recruited or excluded to form …
the cell surface, in which signaling molecules are specifically recruited or excluded to form …
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells
The kinase LCK and CD4/CD8 co-receptors are crucial components of the T cell antigen
receptor (TCR) signaling machinery, leading to key T cell fate decisions. Despite decades of …
receptor (TCR) signaling machinery, leading to key T cell fate decisions. Despite decades of …
Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function
VME Dunlock, AB Arp, SP Singh, S Charrin, V Nguyen… - Cell reports, 2022 - cell.com
T cells depend on the phosphatase CD45 to initiate T cell receptor signaling. Although the
critical role of CD45 in T cells is established, the mechanisms controlling function and …
critical role of CD45 in T cells is established, the mechanisms controlling function and …
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer
Abstract Poly-ADP Ribose Polymerase (PARP) targeted therapy is clinically approved for the
treatment of homologous recombination (HR) repair deficient tumors. The remarkable …
treatment of homologous recombination (HR) repair deficient tumors. The remarkable …
Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation
AL Lanz, G Masi, N Porciello, A Cohnen, D Cipria… - Cell reports, 2021 - cell.com
The mechanism of T cell antigen receptor (TCR-CD3) signaling remains elusive. Here, we
identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide …
identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide …
Trapping or slowing the diffusion of T cell receptors at close contacts initiates T cell signaling
T cell activation is initiated by T cell receptor (TCR) phosphorylation. This requires the local
depletion of large receptor-type phosphatases from “close contacts” formed when T cells …
depletion of large receptor-type phosphatases from “close contacts” formed when T cells …
How the Discovery of the CD4/CD8-p56lck Complexes Changed Immunology and Immunotherapy
CE Rudd - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
The past 25 years have seen enormous progress in uncovering the receptors and signaling
mechanisms on T-cells that activate their various effecter functions. Until the late 1980s …
mechanisms on T-cells that activate their various effecter functions. Until the late 1980s …