Since the advent of single-cell RNA sequencing (scRNA-seq) methodology, single-cell
analysis has become a powerful tool for exploration of cellular networks and dysregulated …

Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the
presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated …

Repetitive exposure to antigen in chronic infection and cancer drives T cell exhaustion,
limiting adaptive immunity. In contrast, aberrant, sustained T cell responses can persist over …

Biologic therapies targeting the IL-23/IL-17 axis have transformed the treatment of psoriasis.
However, the early mechanisms of action of these drugs remain poorly understood. Here …

Background Prurigo nodularis (PN) is a chronic neuroimmune skin disease characterized by
bilaterally distributed pruritic hyperkeratotic nodules on extremities and trunk. Neuroimmune …

Chronic prurigo is a debilitating, difficult-to-treat, and long-neglected disease characterized
by chronic pruritus, signs of repeated scratching, and the presence of pruriginous lesions …

Fibroblasts are among the most abundant cell types in the human body, playing crucial roles
in numerous physiological processes, including the structural maintenance of the dermis …

Dupilumab, an IL4R-blocking antibody, has shown clinical efficacy for atopic dermatitis (AD)
treatment. In addition to conjunctivitis/blepharitis, the de novo appearance of head/neck …

Cancer-associated immune dysfunction is a major challenge for effective therapies. The
emergence of antibodies targeting tumor cell-surface antigens led to advancements in the …

Pruritus is the most common symptom of dermatological disorders, and prurigo nodularis
(PN) is notorious for intractable and severe itching. Conventional treatments often yield …