Influx of sodium ions through voltage-gated sodium channels in cardiomyocytes is essential
for proper electrical conduction within the heart. Both acquired conditions associated with …

Sodium is an essential ion that plays a central role in many physiological processes
including the transmembrane electrochemical gradient and the maintenance of the body's …

Starving therapy based on tumor calcification has been considered as a promising strategy
with high biosafety for tumor treatment. However, the limited calcium (Ca2+) concentration …

Cancers of epithelial origin such as breast, prostate, cervical, gastric, colon and lung cancer
account for a large proportion of deaths worldwide. Better treatment of metastasis, the main …

Several chronic inflammatory diseases have been linked to high-salt (HS) diets. Chronic
inflammation is an established causative hallmark of cancer. However, a direct role of HS …

Cancer is a pernicious and pressing medical problem; moreover, it is a failure of
multicellular morphogenesis that sheds much light on evolutionary developmental biology …

During the second half of the last century, the prevalent knowledge recognized the voltage-
gated sodium channels (VGSCs) as the proteins responsible for the generation and …

Background Metastasis was the major cause of the high mortality in ovarian cancer.
Although some mechanisms of metastasis in ovarian cancer were proposed, few have been …

The development of therapies that can suppress invasion and prevent metastasis,'anti-
metastatic drugs', is an important area of unmet therapeutic need. The new results of a …

Solid tumours have abnormally high intracellular [Na+]. The activity of various Na+ channels
may underlie this Na+ accumulation. Voltage-gated Na+ channels (VGSCs) have been …