Obesity and cancer: existing and new hypotheses for a causal connection

TW Stone, M McPherson, LG Darlington - EBioMedicine, 2018 - thelancet.com
Existing explanations of obesity-associated cancer emphasise direct mutagenic effects of
dietary components or hormonal imbalance. Some of these hypotheses are reviewed briefly …

Involvement of LDL and ox-LDL in cancer development and its therapeutical potential

CF Deng, N Zhu, TJ Zhao, HF Li, J Gu, DF Liao… - Frontiers in …, 2022 - frontiersin.org
Lipid metabolism disorder is related to an increased risk of tumorigenesis and is involved in
the rapid growth of cancer cells as well as the formation of metastatic lesions …

[HTML][HTML] Obesity-induced changes in cancer cells and their microenvironment: Mechanisms and therapeutic perspectives to manage dysregulated lipid metabolism

M Lee-Rueckert, M Canyelles, M Tondo… - Seminars in cancer …, 2023 - Elsevier
Obesity has been closely related to cancer progression, recurrence, metastasis, and
treatment resistance. We aim to review recent progress in the knowledge on the obese …

Hyper-elongation in colorectal cancer tissue–cerotic acid is a potential novel serum metabolic marker of colorectal malignancies

A Mika, J Kobiela, A Czumaj, M Chmielewski… - Cellular Physiology and …, 2017 - karger.com
Abstract Backgrounds/Aims: Colorectal cancer (CRC) cells show some alterations of lipid
metabolism. Elongation of fatty acids (FA) has not been studied in CRC tissues thus far. The …

LOX-1 activation by oxLDL triggers an epithelial mesenchymal transition and promotes tumorigenic potential in prostate cancer cells

I González-Chavarría, E Fernandez, N Gutierrez… - Cancer letters, 2018 - Elsevier
Obesity is related to an increased risk of developing prostate cancer with high malignancy
stages or metastasis. Recent results demonstrated that LOX-1, a receptor associated with …

Tumor‐associated macrophages promote the metastasis and growth of non‐small‐cell lung cancer cells through NF‐κB/PP2Ac‐positive feedback loop

ZW Liang, XX Ge, MD Xu, H Qin, MY Wu… - Cancer …, 2021 - Wiley Online Library
Non‐small‐cell lung cancer (NSCLC), with its aggressive biological behavior, is one of the
most diagnosed cancers. Tumor‐associated inflammatory cells play important roles in the …

LYAR Promotes Colorectal Cancer Progression by Upregulating FSCN1 Expression and Fatty Acid Metabolism

Y Wu, Y Zhou, H Gao, Y Wang, Q Cheng… - Oxidative Medicine …, 2021 - Wiley Online Library
Colorectal cancer (CRC) is a highly malignant tumor associated with poor prognosis, yet the
molecular mechanisms are not fully understood. In this study, we showed that LYAR, a …

[HTML][HTML] Oxidized low-density lipoprotein stimulates CD206 positive macrophages upregulating CD44 and CD133 expression in colorectal cancer with high-fat diet

SM Zheng, H Chen, WH Sha, XF Chen… - World Journal of …, 2022 - ncbi.nlm.nih.gov
BACKGROUND Oxidized low-density lipoprotein (ox-LDL), which is abnormally increased in
the serum of colorectal cancer (CRC) patients consuming a high-fat diet (HFD), may be one …

A novel regulatory facet for hypertriglyceridemia: The role of microRNAs in the regulation of triglyceride-rich lipoprotein biosynthesis

M Khalifeh, RD Santos, RK Oskuee, A Badiee… - Progress in lipid …, 2023 - Elsevier
Atherosclerotic cardiovascular disease (ASCVD) is one of the major leading global causes
of death. Genetic and epidemiological studies strongly support the causal association …

Cholesterol reduces the sensitivity to platinum-based chemotherapy via upregulating ABCG2 in lung adenocarcinoma

Y Wu, R Si, H Tang, Z He, H Zhu, L Wang, Y Fan… - Biochemical and …, 2015 - Elsevier
Inoperable lung adenocarcinoma is currently treated with platinum-based chemotherapy.
However, the effectiveness of these chemotherapeutic agents is not the same for all patients …