BET domain co-regulators in obesity, inflammation and cancer
AC Belkina, GV Denis - Nature reviews Cancer, 2012 - nature.com
The bromodomain is a highly conserved motif of 110 amino acids that is bundled into four
anti-parallel α-helices and found in proteins that interact with chromatin, such as …
anti-parallel α-helices and found in proteins that interact with chromatin, such as …
Drug discovery targeting bromodomain-containing protein 4
BRD4, the most extensively studied member of the BET family, is an epigenetic regulator
that localizes to DNA via binding to acetylated histones and controls the expression of …
that localizes to DNA via binding to acetylated histones and controls the expression of …
CDK9: a comprehensive review of its biology, and its role as a potential target for anti-cancer agents
AT Anshabo, R Milne, S Wang, H Albrecht - Frontiers in oncology, 2021 - frontiersin.org
Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions,
most importantly cell division and transcription, and their dysregulations have been …
most importantly cell division and transcription, and their dysregulations have been …
The RNA polymerase II carboxy-terminal domain (CTD) code
D Eick, M Geyer - Chemical reviews, 2013 - ACS Publications
The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …
nucleic acid-based universal code for the maintenance and inheritance of genetic …
Writers and readers of histone acetylation: structure, mechanism, and inhibition
R Marmorstein, MM Zhou - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Histone acetylation marks are written by histone acetyltransferases (HATs) and read by
bromodomains (BrDs), and less commonly by other protein modules. These proteins …
bromodomains (BrDs), and less commonly by other protein modules. These proteins …
Targeting CDK9 for anti-cancer therapeutics
R Mandal, S Becker, K Strebhardt - Cancers, 2021 - mdpi.com
Simple Summary CDK9, in combination with Cyclin T1, is one of the major regulators of RNA
Polymerase II mediated productive transcription of critical genes in any cell. The activity of …
Polymerase II mediated productive transcription of critical genes in any cell. The activity of …
[HTML][HTML] The role of human bromodomains in chromatin biology and gene transcription
R Sanchez, MM Zhou - Current opinion in drug discovery & …, 2009 - ncbi.nlm.nih.gov
The acetylation of histone lysine is central to providing the dynamic regulation of chromatin-
based gene transcription. The bromodomain (BRD), which is the conserved structural …
based gene transcription. The bromodomain (BRD), which is the conserved structural …
[HTML][HTML] HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP
B Sobhian, N Laguette, A Yatim, M Nakamura, Y Levy… - Molecular cell, 2010 - cell.com
HIV-1 transactivator Tat has greatly contributed to our understanding of transcription
elongation by RNAPII. We purified HIV-1 Tat-associated factors from HeLa nuclear extract …
elongation by RNAPII. We purified HIV-1 Tat-associated factors from HeLa nuclear extract …
Reactivation of latent HIV-1 by inhibition of BRD4
HIV-1 depends on many host factors for propagation. Other host factors, however,
antagonize HIV-1 and may have profound effects on viral activation. Curing HIV-1 requires …
antagonize HIV-1 and may have profound effects on viral activation. Curing HIV-1 requires …
Block-and-lock: new horizons for a cure for HIV-1
I Moranguinho, ST Valente - Viruses, 2020 - mdpi.com
HIV-1/AIDS remains a global public health problem. The world health organization (WHO)
reported at the end of 2019 that 38 million people were living with HIV-1 worldwide, of which …
reported at the end of 2019 that 38 million people were living with HIV-1 worldwide, of which …