Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

The establishment and maintenance of immunological tolerance entails both central and
peripheral mechanisms. The latter have been highlighted in the past several years, mostly …

It has indeed been a distinct honor to be the recipient of the 2002 Outstanding Scientific
Achievement Award, and I was happy to accept it, on behalf of the entire islet transplant field …

Clinical islet transplantation has demonstrated success in treating type 1 diabetes. A current
limitation is the intrahepatic portal vein transplant site, which is prone to mechanical stress …

The CD28-B7 and CD154-CD40 pathways have been described as the critical costimulatory
pathways for T cell activation. Blockade of these pathways has been reported to regulate …

Immunological memory is a hallmark of adaptive immunity, a defense mechanism endowed
to vertebrates during evolution. However, an autoimmune pathogenic role of memory …

Regulatory T cells (Tregs) are essential for the establishment and maintenance of immune
tolerance, suggesting a potential therapeutic role for Tregs in transplantation. However, Treg …

The induction of operational immune tolerance is a major goal in beta-cell replacement
strategies for the treatment of type 1 diabetes. Our group previously reported long-term …

Pancreatic islets and insulinoma cells are particularly vulnerable to serious damage by
cytotoxic nitric oxide (NO) and/or oxidative stress, most probably due to their low expression …

CD40 was originally identified as a receptor on B-cells that delivers contact-dependent T
helper signals to B-cells through interaction with CD40 ligand (CD40L, CD154). The pivotal …