Collective cell migration critically depends on cell–cell interactions coupled to a dynamic
actin cytoskeleton. Important cell–cell adhesion receptor systems implicated in controlling …

Filopodia,“the fingers that do the walking,” have been identified on endothelial cells at the tip
of sprouting vessels for half a century, but the key role of the tip cell in vessel branching has …

The long noncoding RNA MALAT1 (metastasis-associated lung adenocarcinoma transcript
1), also known as MALAT-1 or NEAT2 (nuclear-enriched abundant transcript 2), is a highly …

MicroRNAs play key roles in tumor metastasis. Here, we describe the regulation and
function of miR-218 in gastric cancer (GC) metastasis. miR-218 expression is decreased …

Uveal (ocular) melanoma is an aggressive cancer that often forms undetectable
micrometastases before diagnosis of the primary tumor. These micrometastases later …

Nanomedicine greatly improves the efficiency in the delivery of antitumor drugs into the
tumor, but insufficient tumoral penetration impairs the therapeutic efficacy of most …

Nasopharayngeal carcinoma (NPC) is an Epstein–Barr virus–associated malignancy most
common in East Asia and Africa. Here we report frequent downregulation of the microRNA …

Over the past few years, several genes, proteins and signalling pathways that are required
for embryogenesis have been shown to regulate tumour development and progression by …

Tumors have been recently recognized as aberrant organs composed of a complex mixture
of highly interactive cells that in addition to the cancer cell include stroma (fibroblasts …

The tumor microenvironment (TME) is a complex and heterogeneous environment
composed of cancer cells, tumor stroma, a mixture of tissue-resident and infiltrating immune …