Maintenance of genome stability depends on efficient, accurate repair of DNA damage. DNA
double-strand breaks (DSBs) are among the most lethal types of DNA damage, with the …

Active plant defense, also known as gene-for-gene resistance, is triggered when a plant
resistance (R) gene recognizes the intrusion of a specific insect pest or pathogen. Activation …

Summary The Mre11-Rad50-Nbs1 (MRN) complex is a primary sensor of DNA double-
strand breaks (DSBs). Upon recruitment to DSBs, it plays a critical role in catalyzing 5′→ …

In response to DNA double-strand breaks (DSBs), cells sense the DNA lesions and then
activate the protein kinase ATM. Subsequent DSB resection produces RPA-coated ssDNA …

Notch is a transmembrane receptor that determines cell fates and pattern formation in all
animal species. After ligand binding, proteolytic cleavage steps occur and the intracellular …

The mammalian CtIP protein and its orthologs in other eukaryotes promote the resection of
DNA double-strand breaks and are essential for meiotic recombination. Here we review the …

CtIP interacts with a group of tumor suppressor proteins including RB (retinoblastoma
protein), BRCA1, Ikaros, and CtBP, which regulate cell cycle progression through …

Human CtIP was originally identified as an interactor of the retinoblastoma protein and
BRCA1, two bona fide tumour suppressors frequently mutated in cancer. CtIP is renowned …

Human CtIP is a decisive factor in DNA double-strand break repair pathway choice by
enabling DNA-end resection, the first step that differentiates homologous recombination …

The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic
stem cells and the suppression of carcinogenesis. A key FA protein, FANCD2, is …