Recent advances in B-cell epitope prediction methods
Y El-Manzalawy, V Honavar - Immunome research, 2010 - Springer
Identification of epitopes that invoke strong responses from B-cells is one of the key steps in
designing effective vaccines against pathogens. Because experimental determination of …
designing effective vaccines against pathogens. Because experimental determination of …
Linear B-cell epitope prediction for in silico vaccine design: A performance review of methods available via command-line interface
Linear B-cell epitope prediction research has received a steadily growing interest ever since
the first method was developed in 1981. B-cell epitope identification with the help of an …
the first method was developed in 1981. B-cell epitope identification with the help of an …
epitope3D: a machine learning method for conformational B-cell epitope prediction
The ability to identify antigenic determinants of pathogens, or epitopes, is fundamental to
guide rational vaccine development and immunotherapies, which are particularly relevant …
guide rational vaccine development and immunotherapies, which are particularly relevant …
Monoclonal antibodies against Aβ42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer disease brain
A Hatami, R Albay, S Monjazeb, S Milton… - Journal of biological …, 2014 - ASBMB
Amyloidogenic proteins generally form intermolecularly hydrogen-bonded β-sheet
aggregates, including parallel, in-register β-sheets (recognized by antiserum OC) or …
aggregates, including parallel, in-register β-sheets (recognized by antiserum OC) or …
[HTML][HTML] B-cell epitope mapping for the design of vaccines and effective diagnostics
TA Ahmad, AE Eweida, SA Sheweita - Trials in Vaccinology, 2016 - Elsevier
The increasing resistance of many microbial strains to antibiotics, delayed laboratory results,
and side effects of many chemotherapeutics has raised the need to search for sensitive …
and side effects of many chemotherapeutics has raised the need to search for sensitive …
Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch
M Fresquet, MP Lockhart-Cairns… - Proceedings of the …, 2022 - National Acad Sciences
Membranous nephropathy is an autoimmune kidney disease caused by autoantibodies
targeting antigens present on glomerular podocytes, instigating a cascade leading to …
targeting antigens present on glomerular podocytes, instigating a cascade leading to …
State of the art in epitope mapping and opportunities in COVID-19
The understanding of any disease calls for studying specific biological structures called
epitopes. One important tool recently drawing attention and improving efficiency in both …
epitopes. One important tool recently drawing attention and improving efficiency in both …
The correlation between subolesin-reactive epitopes and vaccine efficacy
Vaccination is an environmentally-friendly alternative for tick control. The tick antigen
Subolesin (SUB) has shown protection in vaccines for the control of multiple tick species in …
Subolesin (SUB) has shown protection in vaccines for the control of multiple tick species in …
In silico prediction of linear B-cell epitopes on proteins
Antibody-protein interactions play a critical role in the humoral immune response. B-cells
secrete antibodies, which bind antigens (eg, cell surface proteins of pathogens). The specific …
secrete antibodies, which bind antigens (eg, cell surface proteins of pathogens). The specific …
Epitope screening using Hydrogen/Deuterium Exchange Mass Spectrometry (HDX‐MS): An accelerated workflow for evaluation of lead monoclonal antibodies
Background Epitope mapping is an increasingly important aspect of biotherapeutic and
vaccine development. Recent advances in therapeutic antibody design and production have …
vaccine development. Recent advances in therapeutic antibody design and production have …