Microglial cells interact with all components of the central nervous system (CNS) and are
increasingly recognized to play essential roles during brain development, homeostasis and …

Emerging evidence indicates that Ca2+ is a vital factor in modulating the pathogenesis of
Alzheimer's disease (AD). In healthy neurons, Ca2+ concentration is balanced to maintain a …

New Findings What is the topic of this review? This paper overviews the links between Ca2+
and Na+ signalling in various types of cells. What advances does it highlight? This paper …

Multiple sclerosis (MS) is a central nervous system disease with complex pathogenesis,
including two main processes: immune-mediated inflammatory demyelination and …

Ca 2+ homeostasis is essential for cell function and survival. As such, the cytosolic Ca 2+
concentration is tightly controlled by a wide number of specialized Ca 2+ handling proteins …

Calcium, an indispensable element in bone tissues, plays a crucial role in various cellular
processes involved in cancer progression. Its ubiquitous yet spatially distinct distribution in …

The sodium/calcium exchanger (NCX) is a unique calcium transport system, generally
transporting calcium ions out of the cell in exchange for sodium ions. Nevertheless, under …

In recent decades, medical research has been primarily focused on the inherited aspect of
cancers, despite the reality that only 5–10% of tumours discovered are derived from genetic …

Abstract Structure-dynamic analysis of archaeal NCX (NCX_Mj) provided new insights into
the underlying mechanisms of ion selectivity, ion-coupled alternating access, ion occlusion …

The plasma-membrane homeostasis Na+/Ca2+ exchangers (NCXs) mediate Ca2+
extrusion/entry to dynamically shape Ca2+ signaling/in biological systems ranging from …