With the increasing risk of invasive and life threating fungal infections, there is now a great
concern regarding the lower discovery rate of antifungal drugs in comparison to …

The Candida genus comprises opportunistic fungi that can become pathogenic when the
immune system of the host fails. Candida albicans is the most important and prevalent …

Alzheimer's disease is a major public brain condition that has resulted in many deaths, as
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …

Thiazole, a unique heterocycle containing sulphur and nitrogen atoms, occupies an
important place in medicinal chemistry. It is an essential core scaffold present in many …

Thiazole is one of the most important scaffolds in heterocyclic chemistry and drug design
and discovery. It is widely found in diverse pharmacologically active substances and in …

Over 30 nitrile-containing pharmaceuticals are prescribed for a diverse variety of medicinal
indications with more than 20 additional nitrile-containing leads in clinical development …

Triazole compounds containing three nitrogen atoms in the five-membered aromatic azole
ring are readily able to bind with a variety of enzymes and receptors in biological system via …

The development of innovative antifungal agents is essential. Some fungicidal agents are no
longer effective due to resistance development, various side effects, and high toxicity …

Invasive fungal infections and systemic mycosis, whether from nosocomial infection or
immunodeficiency, have been on an upward trend for numerous years. Despite …

ABSTRACT Introduction: Invasive fungal diseases (IFDs) are a leading cause of morbidity
and mortality among immunocompromised patients with bone marrow failure syndromes …