The neurovascular unit dysfunction in Alzheimer's disease

LO Soto-Rojas, M Pacheco-Herrero… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide.
Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and …

Amyloid and tau PET in cerebral amyloid angiopathy-related inflammation two case reports and literature review

JY Yang, YT Chu, HH Tsai, JS Jeng - Frontiers in Neurology, 2023 - frontiersin.org
Background Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a clinical
syndrome characterized by MRI findings of amyloid-related imaging abnormalities-edema …

The association between white matter hyperintensities and amyloid and tau deposition

SL Alban, KM Lynch, JM Ringman, AW Toga… - NeuroImage: Clinical, 2023 - Elsevier
White matter hyperintensities (WMHs) frequently occur in Alzheimer's Disease (AD) and
have a contribution from ischemia, though their relationship with β-amyloid and …

Plasma soluble TREM2 is associated with white matter lesions independent of amyloid and tau

HH Tsai, YF Chen, RF Yen, YL Lo, KC Yang, JS Jeng… - Brain, 2021 - academic.oup.com
Cerebral small vessel disease is one of the most common causes of cognitive decline and
stroke. While several lines of evidence have established a relationship between …

[HTML][HTML] Insoluble vascular amyloid deposits trigger disruption of the neurovascular unit in Alzheimer's disease brains

LO Soto-Rojas, BB Campa-Córdoba… - International journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease, characterized histopathologically
by intra-neuronal tau-related lesions and by the accumulation of amyloid β-peptide (Aβ) in …

Longitudinal progression of magnetic resonance imaging markers and cognition in Dutch-type hereditary cerebral amyloid angiopathy

SE Van Dijk, J Van Der Grond, J Lak… - Stroke, 2022 - Am Heart Assoc
Background: Hemorrhagic and ischemic magnetic resonance imaging lesions as well as the
more recently described decrease in vasomotor reactivity have been suggested as possible …

Cerebral amyloid deposition predicts long‐term cognitive decline in hemorrhagic small vessel disease

YC Tsai, HH Tsai, CJ Liu, SS Lin, YF Chen… - Brain and …, 2023 - Wiley Online Library
Background To investigate the association between cerebral amyloid deposition and long‐
term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) and …

Imaging of spontaneous intracerebral hemorrhage

A Jain, A Malhotra… - Neuroimaging …, 2021 - neuroimaging.theclinics.com
Intracerebral hemorrhage (ICH) is defined as extravasation of blood in the cerebral
parenchyma, and it comprises up to 15% of all strokes. 1 ICH is a devastating condition with …

Gender differences in intracerebral hemorrhage

ND Osteraas - Neurologic Clinics, 2023 - neurologic.theclinics.com
Nontraumatic intracerebral hemorrhages (ICHs) are the second most common type of
disabling stroke after ischemic stroke (IS), accounting for around 26% of cases globally. 1 In …

A novel c. 800G> C variant of the ITM2B gene in familial Korean dementia

JM Rhyu, J Park, BS Shin, YE Kim… - Journal of …, 2023 - content.iospress.com
Mutations in ITM2B have been reported to be associated with several familial dementias,
such as Familial British dementia and familial Danish dementia. These are autosomal …